We downloaded allele-specific open chromatin informs functional disease variants from Zhang et al. study. In the original study, Zhang et al. identified thousands of genetic variants exhibiting allele-specific open chromatin (ASoC) by using human induced pluripotent stem cell (iPSC)-derived neurons that model developing brains. We collected this result and identified potential functional SNPs that affect chromatin accessibility during neurodevelopment in bipolar disorder. More details about the data analysis procedure can be found in the original publication. (Zhang et al. 2020. Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants. Science, 369(6503):561-565. [PMID: 32732423]).

If you used the ‘Functional SNPs’ result in this database, please cite the relative references.