Manual

Bipolar disorder (BIP) is one of the most common and severe psychiatric disorders with a heritability estimated to be about 70–90%. In recent years, significant progress has been made to elucidate the genetic and molecular mechanisms underlying bipolar disorder. However, the causal genes and pathways remain largely unclear. Here we developed the bipolar disorder database (dbBIP), a comprehensive resource for bipolar disorder research. Currently, dbBIP collected and integrated bipolar disorder related data from the following source: genetic data (SNP associations from the genome-wide association studies, whole exome sequencing (WES) studies, copy number variants (CNVs) study), gene expression data (spatio-temporal expression pattern, tissue expression data and differentially expressed genes), network-based data (PPI and co-expression), brain eQTL data, integrative analysis data, as well as SNP function annotation information. The dbBIP contains four types of modules: SNP module, Gene module, Analysis module and other module.
Overview diagram of dbBIP:
Cite us:
Xiao-Yan Li#, Shun-Shuai Ma#, Yong Wu, Hui Kong, Ming-Shan Zhang, Xiong-Jian Luo,Jun-Feng Xia*dbBIP: a comprehensive bipolar disorder database for genetic research.(2022).
The dbBIP requires a modern web browser with JavaScript and cookies enabled. To view the complex details, pop-ups must not be blocked. The following browsers have been thoroughly tested with dbBIP:
• Mozilla Firefox, version 4 or above
• Internet Explorer, versions 9 or above
• Chrome, version 5 or above
• The latest version of Firefox and Chrome is recommended for visualization.
Module Entry Dataset Tissue
SNP PGC2 GWAS PGC2 Blood
PGC3 GWAS PGC3 Blood
Functional SNPs Zhang et al. 2020 iPSC-derived neurons
Gene Genes identified by SMR CMC, LIBD2-DLPFC, PsychENCODE, eQTLGen Brain,Blood
Genes identified by TWAS CMC, LIBD2-DLPFC, PsychENCODE Brain
Genes identified by GWAS PGC2, PGC3 Blood
Genes identified by CNVs Green et al.2016 Blood
Genes identified by Exome/Genome Sequencing Literature Blood
Genes expressed differentially in PsychENCODE Gandal et al. 2018 Brain
Analysis Static LocusZoom PGC3 Blood
Gene eQTL query CMC, Fetal brain, PsychENCODE Brain
Transcript eQTL query CMC, PsychENCODE Brain
Protein-Protein interaction Li et al. 2016 Human tissue
Co-expression analysis Gandal et al. 2018 Brain
Expression pattern analysis Brainspan, Braincloud Brain
Tissue expression analysis GTEx Human tissue

In dbBIP, we tried to make it powerful and convenient to be used. This Usage is prepared for the online service. The dbCPM provides the SNP function, gene function, analysis function and download function at present.

• SNPs: The official SNPs symbol
• Gene: The official gene symbol
• eQTLGen: Unraveling the polygenic architecture of complex traits using blood eQTL meta analysis.
• PsychENCODE eQTL: Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.
• CMC eQTL: Gene expression elucidates functional impact of polygenic risk for schizophrenia.
• CMC eQTL: LIBD2-DLPFC eQTL: Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia
• SMR: SMR is a powerful integrative analysis approach and aimed at identifying bipolar disorder risk genes whose expression perturbations may confer disease susceptibility by integrating GWAS summary statistics and expression quantitative trait loci (eQTL) data.
• TWAS: TWAS is another powerful integrative analysis approach and aimed at identifying bipolar disorder risk genes whose expression perturbations may confer disease susceptibility by integrating GWAS summary statistics and expression quantitative trait loci (eQTL) data.
• Chromosome: Select a chromosome
• Genome Position: Input in a chromosomal region

Home:

Users can input your interested gene and then click "Go!" button. they will get a comprehensive search result.

SNP:

PGC2 GWAS & PGC3 GWAS

Users can input some SNPs (one SNP per line) or a genome position and then click "search" button. they will get the results .

Functional SNPs

In this module, users only need to input some SNPs (one SNP per line). they will get the results like figure1.

Figure 1. Options for SNP search and SNP search result.

Gene:

Gene Browser System

In this module, we used the dropdown navigation to visit the Gene Browser System pages.

Genes identified by SMR

In this module, users need to do the following 3 steps: 1. Select PGC2 or PGC3; 2. Select a brain eQTL dataset; 3. Input genes (one gene per line);

Genes identified by TWAS

In this module, users need to do the following 3 steps: 1. Select PGC2 or PGC3; 2. Select a brain eQTL dataset; 3. Input genes (one gene per line);

Genes identified by GWAS

    In this module, users need to select a GWAS and input interested genes (one gene per line) or input a region.

Genes identified by CNVs

In this module, users need to input interested genes (one gene per line) or select interested cytoband or input interested region.

Genes identified by Exome/Genome Sequencing

    In this module, users need to do the following 2 steps: 1. Select de novo or rare; 2. Input genes(one gene per line).

Genes expressed differentially in PsychENCODE

In this module, users only need to input interested genes (one gene per line). In the results page, users can click boxplot to show the box picture.

Analysis:

Static LocusZoom

In this module, users only need to input a SNP or input a interested gene.

Gene eQTL query

In this module, users need to do the following 2 steps: 1. Select a dataset; 2.Input genes(one gene per line) or input SNPs(one SNP per line)

Transcript eQTL query

In this module, users need to do the following 2 steps: 1. Select a dataset; 2.Input transcript ids(one transcript id per line) or input SNPs(one SNP per line) .

Protein-Protein Interaction

In this module, users need to do the following 2 steps: 1.Input genes(one gene per line); 2.Select a display type.

Co-expression analysis

In this module, users need to do the following 2 steps: 1.Input genes(one gene per line); 2.Select a minimum pearson correlation coefficient

Expression pattern analysis

In this module, users need to do the following 2 steps: 1.Input genes(one gene per line); 2.Select a dataset.

Tissue expression analysis

    In this module, users only need to input a interested gene.

Download

We provide the option to download the full database. If you'd like to download it, please click each link to download the data.

Contact

I have a few questions which are not listed above, how can I contact the authors of dbBIP?

Please contact Dr. Junfeng Xia (Email: jfxia@ahu.edu.cn) for details.

• November 30, 2021: dbBIP was formally online.